James N. Ver Hoeve, M.S., Ph.D.
Senior Scientist
University Station, Room 230
2880 University Avenue
Madison, WI 53705
(608) 263-8962
(608) 263-4479
| Degrees: | BA 1972 William Paterson College MS 1979 University of Wisconsin-Madison PhD 1982 University of Wisconsin-Madison |
| Fellowships: | 1982-1985 Post-doctoral fellowship University of Wisconsin-Madison Department of Ophthalmology and Visual Sciences. |
| Research: | Photons entering the eye are captured by photoreceptors and initiate a complex series of cellular events resulting in changes in the electric field of the eye and brain. The light-evoked electric field of the retina (electroretinogram) consists of negative and positive voltage 'waves' that are similar across many species. These electric fields can be measured non-invasively and have proven useful in clinical diagnosis of inherited retinal disorders and toxic reactions. The electroretinogram is also a valuable tool for translational research: When working with an animal model of human disease the electroretinogram is used to determine whether retinal electrical function as been altered by a potential therapeutic compound. In addition to my clinical interests in visual electrophysiology, I have been studying the effect of various neuroprotective strategies using the non-invasive electroretinogram and cortical visual evoked potentials as outcome measures. A significant portion of the recent research has been devoted to validating new assessment methods in various species. In collaboration with Dr. T. Michael Nork, we have used the multifocal electroretinogram to assess outer retinal changes in experimental glaucoma. We are currently investigating the role that outer retinal ischemia may play in ganglion cell death in this disease. Recently I have become interested in the effects of long-wavelength on wound healing in the retina using multifocal electroretinography and visual evoked potentials as outcome measures. In addition, I have collaborated with Dr. Chris Murphy of the UW school of veterinary medicine on a number of projects using electroretinography and cortical potentials to assess visual status in rats, dogs and hawks. |
| Publications: | Kiland, J.A., Miller, C.L., Kim, C.B.Y., Ver Hoeve, J. N., Gabelt, B.A., Peterson, J., Nork, T.M. (2006) Effect of H7 on retinal physiology. Current Eye Research, 31:441-455. Nork TM, Kim CB, Shanmuganayagam D, Van Lysel MS, Ver Hoeve JN, Folts JD. (2006) Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres. Archives of Ophthalmology, 124:860-868. Pelzel, HR, Schlamp, CL, Poulsen, GL, Ver Hoeve, JN, Nork, TM, Nickells RM. Loss of cone opsin mRNA in non-human primates with experimental glaucoma,(2006) Molecular Vision, 12:1272-1282. Maertz, NA, Kim, CBY, Nork, TM, Levin, LA, Lucarelli, MJ, Kaufman, PL, Ver Hoeve, JN. (2006) Multifocal visual evoked potentials in the anesthetized non-human primate, Current Eye Research , 31:885-593. Nickells, RW, Schlamp, CL, Li, Y, Kaufman, PL, Heatley, GA, Peterson, JC, Faha, B, Ver Hoeve, J Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease, Experimental Eye Research, (in press) Gillingham MB, Weleber RG, Neuringer M et al. Effect of optimal dietary therapy upon visual function in children with long-chain 3-hydroxyacyl CoA dehydrogenase and trifunctional protein deficiency. Molecular Genetics and Metabolism. 2005, 86. 124-133. Kim, C.B.Y, Ver Hoeve, J.N., Kaufman, P.L., Nork, T.M. (2005) Effect of reference electrode location on monopolar-derived multifocal electroretinogram in cynomolgus monkeys. Documenta Ophthalmologica, 111:113-125. Walters, B.A.,Raff, M..L, Ver Hoeve, J.N., Tesser, R., Langer, L.O., France,T.D., Glass, .IA., Pauli, R.M. Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy (2004), American Journal of Medical Genetics, 129A, 265-276. Eells JT, Wong-Riley MT, Ver Hoeve J et al. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004;4:559-67. Kim CB, Ver Hoeve JN, Kaufman PL, Nork TM. Interspecies and gender differences in multifocal electroretinograms of cynomolgus and rhesus macaques. Documenta Ophthalmologica 2004;109:73-86. Nork TM, Poulsen G.L., Nickells R.W., Ver Hoeve J.N., Cho N.C, Levin L.A., Lucarelli M.J. (2000) Protection of ganglion cells in experimental glaucoma by retinal laser photocoagulation. Archives of Ophthalmology 118, 1242-1250. Ver Hoeve, J. N., Danilov, Y. ,Kim, CBYK, and Spear, P.D. (1999) VEP and PERG acuity in anesthetized young adult rhesus monkeys. Visual Neuroscience, 16, 607-617. Hess, R. F., Baker, C. L., Ver Hoeve, J. N., Tulunay-Keesey, U., & France, T. D. (1985). The pattern evoked electroretinogram: Its variability in normals and its relationship to amblyopia. Investigative Ophthalmology and Visual Science, 11, 1610-1623. |